Many times, Diabetes is associated with (either precipitated by or worsened by) underlying endocrine disorders. Course of diabetes directly co relates with underlying other endocrine cause. The four-outer regulatory anti insulin hormones present as a contrarian bet. Endocrine causes are not as uncommon as we think. It’s extremely important to identify as they are the ones responsible for severity of diabetes; complications associated with diabetes; onset of diabetes in most of the cases. Identifying and treating them can favourably modify the course of diabetes.