Liquor use and torment are regular issues among individuals living with HIV/AIDS (PLWHA). Subsequently, expanding the comprehension of the collaboration between these ailments is basic to further develop medical care and personal satisfaction for this populace. While distinctions in sexual orientation in liquor use and state of mind problems are broadly perceived, little is had some significant awareness of orientation incongruities in solution of pain relievers and connects. Similarly significant is the absence of data in regards to the job of neurotrophic factors albeit creature models have shown BDNF pronociceptive impacts.