Introduction and importance: A rare cranial malignant hematological malignancy is Primary Central Nervous System Lymphoma (PCNSL). Compared to other encephalic regions, PCNSL in the cerebellum is less frequent. Cerebellar PCNSL has a variety of imaging presentations, making a diagnosis rather challenging. The purpose of this case series study is to examine the impact of surgery on cerebellar PCNSL and whether surgery might be utilized to confirm the diagnosis.
Methods: We present three examples of cerebellar PCNSL treated with general anaesthesia by neuronavigation microsurgery. The procedure was carried out by authors. Due to postoperative obstructive hydrocephalus, one patient received left lateral ventricular drainage on the fourth and tenth days after the procedure. Following histology confirmation, all patients received chemotherapy or radiation treatment.
Results: The malignancies in every patient were entirely eliminated. One patient underwent surgery; experienced perioperative obstructive hydrocephalus twice, was treated with drainage, and eventually left the hospital after making a full recovery. The other two patients made a full recovery and were released without incident. Nine months after the surgery, one patient passed away, but the other two patients lived.
Three patients' prognoses were influenced by the size of the tumour and prompt follow-up chemo-radiation therapy. All patients' histologies revealed diffuse large B-cell lymphoma (GCB phenotype). Patients with suspected cerebellar PCNSL should have surgery to make the diagnosis, and then get radiotherapy and chemotherapy.