Nitric Oxide (NO), commonly known as nitrogen monoxide, is a colorless, poisonous gas created when nitrogen is oxidised. And it has a number of uses in medicine and plays a significant role in chemical signaling in both humans and other animals. The cellular messenger Nitric oxide (NO) is produced by three different isoforms of Nitric Oxide Synthases (NOS), including neuronal (nNOS), inducible (iNOS), and endothelial NOS (eNOS). The prevention of the development and progression of cardiovascular disease is significantly aided by NO. Hypercholesterolemia, hypertension, and diabetes are only a few of the illnesses that cardiovascular disease is linked to. Most cardiovascular disorders have atherosclerosis as their underlying pathology, which is linked to endothelial dysfunction. NO plays a number of cardio protective activities, including controlling blood pressure and vascular tone, preventing smooth muscle cell growth, and inhibiting platelet aggregation and leukocyte adhesion. This review will concentrate on the function of NO in the cardiovascular system, where it inhibits platelet adhesion and aggregation, maintains a vasodilator tone, and controls smooth muscle cell proliferation. Numerous cardiovascular disorders have been linked to NO, and almost all of these risk factors appear to be connected to a decrease in endothelial NO production.